_________（48）A.In spite of this handicap however
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_________（48）
A.In spite of this handicap,however,he continued to write music.
B.Because of irregular payments from his publishers and erratic support from his patrons,he was troubled by financial worries throughout his adult life.
C.His life was marked by a passionate dedication to independence.
D.When his mother died,Beethoven,then a young man,was named guardian of his two younger brothers.
E.Although Beethoven’s personality may have been untamed,his music shows great discipline and control,and this is how we remember him best.
F.Today his music is still being played all over the world.
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答案：A
本题考查的是对上下文之间意义关系的理解和对文章细节的把握。句中的this handicap承接上段，指上段最后一句话提到的耳聋这一残疾，全句的意思是说贝多芬身残志坚，继续音乐创作。原文最后一句列举了贝多芬的音乐成就，此处选A与上下文街接自然，意思连贯。